Biofilms are special membrane tissues that microorganisms use to maintain their survival against external stressful conditions. Biofilms are usually surrounded by an extracellular polymer (EPS) matrix that confers bacterial resistance to bactericides, antibiotics, and other invasions. Biofilm formation is directly responsible for the development of more than 90% of antibiotic resistance in clinical practice. It is likewise linked to the development of drug resistance (biofilm formation at the lesion due to bacterial infection) in tumors, diabetes and neurological diseases. In addition, biofilm formation poses a significant risk to several industries, such as corrosion of metal precision instruments, water environment pollution, food contamination, etc. It is necessary to explore the research on microbial biofilms and analyze the molecular mechanism of their formation.
Creative Proteomics provides biofilm metabolomics solutions for industrial and academic customers. Based on targeted metabolomics and untargeted metabolomics strategies, we combine other technologies to analyze the functional metabolites that regulate biofilm formation from the perspective of small molecule metabolism and explore the metabolic mechanism of biofilm formation. We provide data to support the removal of biofilm formation in different fields and inhibit its toxic and harmful effects.