Gut Microbiota Metabolomics Services

Gut Microbiota Metabolomics Solutions:

• Study of metabolite dynamics in gut microbiota
• Screening for differential metabolites of gut microbiota
• Study the mechanism of the role of gut microbiota in disease development

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The human gastrointestinal tract is symbiotic with a structurally complex and abundant microbiota. The host and intestinal flora co-metabolize a large number of small molecule metabolites when involved in the metabolism of food or exogenous substances. These metabolites penetrate the intestinal epithelial barrier or otherwise enter the body's circulation, which in turn activates a series of signaling pathways that affect the host's physiological processes. Dysbiosis of intestinal flora is closely associated with the development of many diseases such as obesity, diabetes, non-alcoholic fatty liver, inflammatory bowel disease, and tumors.

Creative Proteomics provides gut microbial metabolomics solutions to detect the dynamic changes of enterobacterial metabolites and clearly demonstrate the metabolic status of gut flora in the host, which can more intuitively study the relationship between gut flora and disease development, thus providing new ideas for disease prevention and treatment, and improving the health of the host.

Metabolomics Analysis Strategies for Gut Microbiota Research

• Gut microbiota untargeted metabolomics analysis: Analyze metabolic spectrum, analyze metabolic level dynamic changes, study known and unknown metabolites, screen differential metabolites.

• Covering 2800+ species and 1200+ metabolites related to intestinal flora, with a large number of metabolites and strains
• Metabolites of many species can be classified retrospectively, and metabolites can be traced to strains
• Metabolites can determine upstream and downstream relationships (none if they are reversible) and regulatory genes/enzymes

• Gut microbiota targeted metabolomics analysis: High-throughput absolute quantitative detection of multiple metabolites. We can analyze the following classes of compounds, including but not limited to:

• Gut microbiota lipidomic analysis: phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), sphingomyelin (SM), triglyceride (TG), ceramide (Cer) and other lipid molecules can be detected.

Gut Microbiota Metabolomics Analysis Process

Sample Requirements

• Serum/Plasma ≥ 200 ul/sample
• Cell ≥ 1×10⁷/sample
• Culture solution ≥ 200 ul/sample
• Stool and intestinal contents ≥ 200 mg/sample

For other sample types, please consult our technicians.

Creative Proteomics is a well-established partner in life science research and has extensive experience in metabolomics analysis. We provide solutions for gut microbiota research in the direction of metabolomics analysis, accelerating the exploration of new horizons in science. If you want to know more, please contact us. Looking forward to cooperating with you.