Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Microbial Metabolomics Service

Microbial Metabolomics Service

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Creative Proteomics committed to providing reliable and cost-effective microbial metabolomics services for academia and various industries. Our services include microbial untargeted metabolomics services and target metabolomics services. Different solutions will be customized according to your purpose and samples, from sample processing to bioinformatics analysis.

Overview

The microbial genome is small, and the data obtained by genomics, transcriptomics, and proteomics are relatively small compared to eukaryotes, and metabolome research will not be affected by this. There are probably at least 20,000 kinds of microbial metabolites that have been elucidated. With the aid of microbial cell metabolite full-component analysis, it can reflect the cell's response to environmental and genetic changes, and promote a comprehensive understanding of the physiological functions of microorganisms.

There is a close relationship between the microbial flora and the host. For example, changes in the composition of the intestinal flora and its metabolites may be related to various factors such as disease, obesity, and diet. Analyzing the microbial metabolome can help to find the microorganisms and metabolites that play a key role in the physiological and disease processes, and reveal the mechanisms of physiological processes and disease occurrence and development.

Microbial metabolomics has been widely used in different research fields, such as the identification and mutation breeding of microorganisms, functional gene research, metabolic engineering and fermentation engineering.

Based on high-resolution mass spectrometry technology, our company has established a metabolomics research platform for microbial primary metabolites and secondary metabolites, help you explore the relationship between biological problems and metabolites and microorganisms, find highly related metabolites and microorganisms, and then explore the internal network of metabolites, microorganisms and biological background. We will customize different solutions according to your samples to accurately identify and quantitatively analyze microbial metabolites.

Microbial Metabolomics Analysis in Creative Proteomics

Untargeted Metabolomics ServiceTargeted Metabolomics Service
Perform a comprehensive, non-focused qualitative and quantitative analysis of the sample. Find out different metabolites through comparison, and combine with biological information analysis to find out enrichment differential pathways.Determination of the absolute concentration of the target metabolite of the sample.

Instrumentation

Creative Proteomics employs state-of-the-art LC-MS/MS and GC-MS/MS systems for microbial metabolomics studies.

Our primary instruments include:

  • AN Sciex Qtrap 6500 Plus
  • AB 5600 Triple TOF
  • Agilent 7890-5977
  • Thermo TSQTM 9000

Workflow for quantitative microbial metabolome analysisWorkflow for quantitative microbial metabolome analysis (van et al., 2007)

Data Analysis

  • Quality control: QC sample results including TIC and PCA results
  • Univariate analysis: T test and/or ANOVA analysis of all identified metabolites
  • Differential metabolite screening: PCA, PLS-DA
  • Clustering analysis: hierarchical clustering analysis, K-means, etc.
  • Metabolic pathway enrichment analysis

Applications of Microbial Metabolomics

1. Research on disease markers, disease mechanism, and drug metabolism

2. Screening and identification of strains, analysis of metabolic pathways, fermentation engineering and probiotic effects

3. Research on gut microbiome and metabolomics in host physiology, disease pathology, drug pharmacology, etc.

4. Food safety evaluation, nutrition evaluation, etc.

Creative Proteomics offers microbial metabolomics service and deliver precise and detailed data and analysis report. If you want to find other metabolomics services but have not found them, you can tell us through the inquiry form, and our technicians will communicate with you.

Reference

  1. van der Werf, M. J., Overkamp, K. M., et al. (2007). Microbial metabolomics: toward a platform with full metabolome coverage. Analytical biochemistry, 370(1), 17-25.

Related Services

Plant Targeted Metabolomics

Animal Targeted Metabolomics

Untargeted Metabolomics Service

Targeted Metabolomics Service

For Research Use Only. Not for use in diagnostic procedures.

Metabolomics Service
5%-20% Discount

Expires: Nov.15 — Dec.5, 2021

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