Metabolic Pathways Analysis

Untargeted metabolomics and targeted metabolomics analysis strategies, combined with multivariate statistical analysis (e.g., principal component analysis, partial least squares discriminant analysis, orthogonal partial least squares discriminant analysis) and metabolic correlation network analysis, are used to explore the metabolic pathways and metabolic mechanisms involved in the disorders.

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Metabolic pathways are vast networks of biochemical reactions that maintain biological function and include highly conserved metabolic pathways composed of a series of chemical reactions necessary to maintain and regulate life activities. Metabolic pathway analysis can identify metabolite clusters associated with key cellular signaling and metabolic networks and provide insight into the biological potential of differentially expressed metabolites. In metabolic pathways, there may be many metabolites with very similar chemical structures and polarities, and multiple pathways are needed to obtain quantitative information on multiple species of metabolites.

Creative Proteomics provides metabolic pathway analysis solutions for a wide range of biological samples such as blood, urine, saliva, tears, animal and plant tissues, providing metabolite assays covering multiple metabolic pathways such as amino acid, tricarboxylic acid cycle, glycolysis, nucleic acid metabolism, and hormone metabolism.

Targeted Metabolic Pathways That We Can Analyze

1. Metabolism: including carbohydrate metabolism, energy metabolism, lipid metabolism, nucleotide metabolism, amino acid metabolism and other related pathways.

2. Genetic information processing: including transcription, translation, folding, sorting, degradation, replication and repair and other related pathways.

3. Environmental information processing: including membrane transport, signal transduction, signal molecule interactions and other related pathways.

4. Cellular processes: including transport and metabolism, cell growth and death, cell communities, cell motility and other related pathways.

5. Organismal systems: including immune system, endocrine system, circulatory system, digestive system, nervous system and other related pathways.

6. Human diseases: including tumors, immune diseases, neurodegenerative diseases, cardiovascular diseases, endocrine metabolic diseases, drug resistance and other related pathways.

7. Drug development: including anti-infective drugs, anti-tumor drugs, neurological drugs and other related pathways. Also includes pathways related to targeted drugs, such as G protein-coupled receptor pathway, nuclear receptor pathway, ion channel pathway, transporter protein pathway, enzyme pathway, etc.

Feature metabolic pathways:

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Reference

1. Lu, Z., He, X., et al. (2018). Serum metabolomics study of nutrient metabolic variations in chronic heat-stressed broilers. British Journal of Nutrition, 119(7), 771-781.