Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Sphingolipid Metabolism Service

Sphingolipid Metabolism Service

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Creative Proteomics is a pioneer in metabolism service and provides reliable, professional and cost-effective sphingolipid metabolism analysis service in animal. We leverage our rich experience, professional expertise, and advanced technologies to speed up your scientific purposes of sphingolipid metabolism analysis in animal.

Overview

Sphingolipids are a class of lipids with eighteen carbon amino-alcohol backbones synthesized from nonsphingolipid precursors. The different modifications of this basic structure leading to a large number of sphingolipids. Although sphingolipids contain various structures and functions, the biosynthesis and degradation pathway for these sphingolipids are the same. Therefore, the sphingolipid metabolism is a mutual network different from a single common biosynthesis pathway and converge into a single common degradation pathway. The simplest forms of sphingolipids are sphingosine, phytosphingosine and dihydrosphingosine. They function as the backbones for other complex groups of sphingolipids. These compounds play important roles in signal transduction and cell recognition. Disorders of sphingolipid metabolism links to various human diseases like Gaucher disease and Fabry disease. Understanding how the sphingolipid metabolism is regulated via contributes to exploring the underlying mechanism behind human diseases. In Creative Proteomics, we provide reliable, rapid and cost-effective sphingolipid metabolism related service to speed up your research aims ranging from diseases diagnosis to gaining new insights in disease mechanism or treatment.

The Main Applications of Sphingolipid Metabolism Service

Identifying novel biomarkers of diseases

Improving diagnose diseases

Accelerating development of novel drugs

Gaining new mechanism of diseases

Advantages of Our Sphingolipid Metabolism Service

Constantly optimized protocol and analytical software

Professional experiment design

Quick turnaround time

High accuracy, specificity, and sensitivity

Service Workflow

Creative Proteomics provides sphingolipid metabolism analysis service in a reliable and effective manner, based on our cutting-edge high-performance liquid chromatography (HPLC) platforms. The experimental procedures contain four main procedures: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

Sphingolipid Metabolism.jpg Figure 1. The overall workflow of sphingolipid metabolism.

List of Partial Detectable Sphingolipid Metabolism Related Metabolites at Creative Proteomics
SphingosinePhytosphingosineDihydrosphingosinePhytoceramideDihydroceramide
CeramideSphingomyelinPhosphoethanolamineLactosylceramideSphingosyl-phosphocholine
DihydrosphingosineGlucosylceramideSphinganine 1-phosphateGalactosylceramideDigalactosylceramide

Sample Requirements

We can analyze a wide range of biological materials including but not limited to cells and solid tissues from humans and animals, such as mice, rats, rabbits. If you need transport your samples to us, please follow the following requirements for different types of sample:

  • Blood/plasma: 500ul/sample
  • Urine: 1ml/sample
  • Tissue: 200mg/sample
  • Cells: 1x107/sample
  • Feces: 500mg/sample
  • Shipment condition: dry ice

Report Delivery

  • Experimental protocols
  • Instrumental factors of HPLC
  • The raw data files of HPLC and the summary of HPLC data quality
  • Bioinformatics analysis report

Based on advanced HPLC platforms for the determination of sphingolipid metabolism, professional bioinformatic analysis software and experienced technicians and scientists, Creative Proteomics provides customer-tailored sphingolipid metabolism analysis service with rapid experimental procedures and easy to read report, to accelerate your scientific research.

References

  1. Kolter Thomas, Sandhoff Konrad. Sphingolipid metabolism diseases. Biochim Biophys Acta. 2006.1758:2057-2079.
  2. Hannun Yusuf A, Obeid Lina M. Sphingolipids and their metabolism in physiology and disease. Nat Rev Mol Cell Biol. 2018.19:175-191.
For Research Use Only. Not for use in diagnostic procedures.

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