Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Glycerolipid Metabolism Service

Glycerolipid Metabolism Service

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Creative Proteomics is a pioneer in metabolism service and provides reliable, professional and cost-effective glycerolipid metabolism analysis service in animal. We leverage our rich experience, professional expertise, and advanced technologies to speed up your scientific purposes of glycerolipid metabolism analysis in animal.

Overview

The glycerolipids are a large group of biological lipids with physiological roles in membrane formation, caloric storage, and crucial intracellular signaling processes. These lipids are constructed upon an sn-lycerol-3-phosphate backbone scaffold by the attachment of long-chain acyl and alkyl groups, and a collection of polar alcohols. Phosphatidic acid is a central intermediate that is metabolized to either cytidine 5'-diphosphate-diacylglycerol for the synthesis of anionic lipids, or diacylglycerol for the synthesis of zwitterionic and uncharged lipids. The final acyl constituents present in different glycerolipid classes are defined by dynamic remodeling reactions. Therefore, any enzymes in these steps will interfere with glycerolipid metabolism and lead to various human diseases like glycerol kinase deficiency and hyperlipoproteinemia. Knowing the abnormal glycerolipid metabolism contribute to unravelling the underlying mechanism behind human diseases. In Creative Proteomics, we provide reliable, rapid and cost-effective glycerolipid metabolism related service to speed up your research aims ranging from diseases diagnosis to gaining new insights in disease mechanism or treatment.

The Main Applications of Glycerolipid Metabolism Service

Identifying novel biomarkers of diseases

Improving diagnose diseases

Accelerating development of novel drugs

Gaining new mechanism of diseases

Advantages of Our Glycerolipid Metabolism Service

Constantly optimized protocol and analytical software

Professional experiment design

Quick turnaround time

High accuracy, specificity, and sensitivity

Service Workflow

Creative Proteomics provides glycerolipid metabolism analysis service in a reliable and effective manner, based on our cutting-edge high-performance liquid chromatography (HPLC) platforms. The experimental procedures contain four main procedures: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

Glycerolipid Metabolism.jpgFigure 1. The overall workflow of glycerolipid metabolism.

List of Partial Detectable Glycerolipid Metabolism Related Metabolites at Creative Proteomics
1-Acyl-sn-glycerol 3-phosphateD-GalactosyldiacylglycerolGlyceraldehyde-3-phosphateGlycerol-3-phosphate
1,2-Diacyl-3-alpha-D-glucosyl-sn-glycerol3-D-Glucosyl-1,2-diacylglycerol1,2-Diacyl-sn-glycerolPhosphatidic acid
sn-Glycerol 3-phosphate3-phosphoglycerate

Sample Requirements

We can analyze a wide range of biological materials including but not limited to cells and solid tissues from humans and animals, such as mice, rats, rabbits. If you need transport your samples to us, please follow the following requirements for different types of sample:

  • Blood/plasma: 500ul/sample
  • Urine: 1ml/sample
  • Tissue: 200mg/sample
  • Cells: 1x107/sample
  • Feces: 500mg/sample
  • Shipment condition: dry ice

Report Delivery

  • Experimental protocols
  • Instrumental factors of HPLC
  • The raw data files of HPLC and the summary of HPLC data quality
  • Bioinformatics analysis report

Based on advanced HPLC platforms for the determination of glycerolipid metabolism, professional bioinformatic analysis software and experienced technicians and scientists, Creative Proteomics provides customer-tailored glycerolipid metabolism analysis service with rapid experimental procedures and easy to read report, to accelerate your scientific research.

References

  1. Huq A H, Lovell R S, Ou C N, et al. X-linked glycerol kinase deficiency in the mouse leads to growth retardation, altered fat metabolism, autonomous glucocorticoid secretion and neonatal death. Hum Mol Genet. 1997.6:1803-1809.
  2. Murthy V, Julien P, Gagne C. Molecular pathobiology of the human lipoprotein lipase gene. Pharmacol Ther. 1996.70:101-135.
For Research Use Only. Not for use in diagnostic procedures.

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