Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Linoleic Acid Metabolism Service

Linoleic Acid Metabolism Service

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Creative Proteomics is a pioneer in metabolism service and provides reliable, professional and cost-effective linoleic acid metabolism analysis service in animal. We leverage our rich experience, professional expertise, and advanced technologies to speed up your scientific purposes of linoleic acid metabolism analysis in animal.

Overview

Linoleic acid is a polyunsaturated omega-6 fatty acid. As the two families of essential fatty acids, animals must ingest linoleic acid from diet because the body requires them but cannot synthesize them by themselves. In the body linoleic acid is a metabolic precursor to some long-chain polyunsaturated fatty acids via desaturation and elongation, which happen in the endoplasmic except for the final step which requires translocation to peroxisomes for partial beta-oxidation. Because of this, linoleic acid metabolism can provide many kinds of polyunsaturated fatty acids, which is necessary for good health. Therefore, aberrant linoleic acid metabolism in the procedure of desaturation and elongation lead to various diseases in animals. Scientists at Creative Proteomics utilize a highly quantitative method with high-performance liquid chromatography (HPLC) for the determination of Linoleic Acid levels in various samples. Scientists at Creative Proteomics utilize a highly quantitative method with high-performance liquid chromatography (HPLC) for the determination of Linoleic Acid levels in various samples. This methodology provides accurate, reliable, and reproducible results of linoleic acid and its relevant metabolites measurement, which speeds up your research aims ranging from diseases diagnosis to gaining new insights in disease mechanism or treatment.

The Main Applications of Linoleic Acid Metabolism Service

  • Identifying novel biomarkers of diseases
  • Improving diagnose diseases
  • Accelerating development of novel drugs
  • Gaining new mechanism of diseases

Advantages of Our Linoleic Acid Metabolism Service

  • Constantly optimized protocol and analytical software
  • Professional experiment design
  • Quick turnaround time
  • High accuracy, specificity, and sensitivity

Service Workflow

Creative Proteomics provides linoleic acid metabolism analysis service in a reliable and effective manner, based on our cutting-edge HPLC platforms. The experimental procedures contain four main procedures: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

The overall workflow of linoleic acid metabolismFigure 1. The overall workflow of linoleic acid metabolism

List of Partial Detectable Linolenic Acid Metabolism Related Metabolites at Creative Proteomics

(9R,10S)-(12Z)-9,10-Epoxyoctadecenoic acid9(S),12(S),13(S)-Trihydroxy-10(E)-octadecenoic acid(9Z,11E)-13-Oxooctadeca-9,11-dienoic acid
(10E,12Z)-9-Oxooctadeca-10,12-dienoic acid(8R,9Z,12Z)-8-Hydroperoxyoctadeca-9,12-dienoate(13S)-Hydroxyoctadecadienoic acid
13S-Hydroperoxy-9Z,11E-octadecadienoic acid(11E)-9,10,13-Trihydroxyoctadec-11-enoic acid9,10-12,13-Diepoxyoctadecanoate
Dihomo-gamma-linolenatDocosapentaenoic acidGamma-Linolenic acid
ArachidonateLinoleate 

Sample Requirements

We can analyze a wide range of biological materials including but not limited to cells and solid tissues from animals. If you need transport your samples to us, please follow the following requirements for different types of sample:

  • Blood/plasma: 500ul/sample
  • Urine: 1ml/sample
  • Tissue: 200mg/sample
  • Cells: 1x107/sample
  • Feces: 500mg/sample
    Shipment condition: dry ice

Report Delivery

  • Experimental protocols
  • Instrumental factors of HPLC
  • The raw data files of HPLC and the summary of HPLC data quality
  • Bioinformatics analysis report

Based on advanced HPLC platforms for the determination of linoleic acid metabolism, professional bioinformatic analysis software and experienced technicians and scientists, Creative Proteomics provides customer-tailored linoleic acid metabolism analysis service with rapid experimental procedures and easy to read report, to accelerate your scientific research.

References

  1. Choque Benjamin, Catheline Daniel, Rioux Vincent, et al. Linoleic acid: between doubts and certainties. Biochimie. 2014.96:14-21.
  2. Taha Ameer Y. Linoleic acid-good or bad for the brain? NPJ Sci Food. 2020. 4:1.
For Research Use Only. Not for use in diagnostic procedures.

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