Diabetes mellitus is a metabolic disorder caused by a combination of environmental and genetic factors. The number of people with diabetes is increasing every year, and the incidence of the disease is becoming younger. Further research on diabetes is urgently needed.
Metabolomics has the advantages of high throughput, speed and low invasiveness, and is therefore widely used in clinical disease research. Metabolites are downstream of the body's response, and upstream activities such as gene transcription and translation, protein synthesis and regulation in vivo are reflected at this level. At the same time, the influence of the external environment also directly affects the body's metabolism. Therefore, metabolomics is the technique of choice to examine and study changes in the body from a phenotypic perspective. This is reflected in the study of disease by the examination, comparison and analysis of metabolic differences in patients with disease.
The applications of metabolomics in diabetes research include the exploration of pathogenic mechanisms, screening of biomarkers, early diagnosis of disease, evaluation of drug efficacy, and disease prognosis.
Creative Proteomics provides diabetes metabolomics solutions to accelerate the progress of diabetes-related research projects.
Diabetes Metabolomics Solutions
- Diabetes biomarker research
They mainly focus on amino acids (including branched-chain amino acids, aromatic amino acids, etc.), fatty acids (free fatty acids, long-chain fatty acids), lipids (phospholipids, etc.), organic acids, sugars and other metabolites, and to a lesser extent, nucleotides and acylcarnitines. The metabolic pathways involved mainly include amino acid metabolism, energy metabolism, fatty acid metabolism, etc., all of which are highly relevant to the development of diabetes.
- Defining differential metabolic pathways through biomarker enrichment to deepen the understanding of diabetes pathogenesis
- Early diagnosis and prediction of diabetes through biomarker comparison and modeling, leading to early intervention in diabetes
- Evaluation of the efficacy of clinical treatment of diabetes through the trend of biomarker changes, thus promoting the development of individualized medicine
- Research on the pathogenesis of diabetes mellitus
The pathogenesis of diabetes involves a combination of environmental and genetic factors. Analysis obtained only at the genetic level is difficult to elucidate the complex environmental effects and the role and influence of the body's metabolism on the development of diabetes. Metabolomics, as a technical discipline to study the downstream metabolism of the organism, provides a more comprehensive and reliable complement to the study of the metabolic mechanisms of diabetes pathogenesis.
Metabolomics Analysis Process for Diabetes
Technology Platform for Metabolomics Analysis
Multiple analytical platforms, including GC-MS, LC-MS, UPLC-MS. Thousands of metabolites can be screened from a single biological sample, providing a comprehensive approach for probing disease mechanisms.
|GC (Q Exactive) (- mode MS)|
HPLC: HILIC (+/- mode MS)
HPLC: RP C18 (+/-mode MS)
IC (- mode MS)
|Q Exactive MS|
Orbitrap Tribrid MS
Creative Proteomics is a well-established partner in biopharmaceutical research and has extensive experience in metabolomics analysis. We provide solutions for diabetes in the direction of metabolomics analysis, accelerating the exploration of new horizons in science. If you want to know more, please contact us. Looking forward to cooperating with you.
For Research Use Only. Not for use in diagnostic procedures.