Quinone compounds mostly have phenolic or hydroxyl groups, and are mainly divided into four types of benzoquinone, naphthoquinone, anthraquinone and phenanthrenequinone compounds and their derivatives. They play an important role in the fields of medicine, pesticides, and dyes. Quinones play an important role in the enzymatic browning of fruits and vegetables, and may form covalent adducts with amino acids, peptides and proteins. These reactions may change the physicochemical and immunological properties of food proteins. Therefore, quinones are widely used as antioxidants, preservatives, coloring agents and flavoring agents in foods. UPLC-MS/MS has the characteristics of fast analysis speed, high selectivity, high sensitivity, high accuracy, high stability and high throughput. It is the main identification and quantitative analysis method of quinones and their metabolites, which increases researchers’ understanding of the functional analysis and mechanism of action of the active molecules of quinone compounds.
Figure 1. Simplified scheme of redox reactions of quinones. Nu = nucleophile. (Schieber 2018).
Creative Proteomics presents an array of quinones analysis services that transcend the conventional boundaries of inquiry. Our mission is to unravel the mysteries surrounding quinones and their metabolites, shedding light on their roles within the intricate web of cellular dynamics. Our suite of services encompasses a comprehensive spectrum of quinones analysis, including:
Quinone Identification: Armed with cutting-edge mass spectrometry technologies, Creative Proteomics embarks on precise identification journeys, unraveling the enigmatic identities of quinones and their elusive metabolites lurking within complex biological samples.
Quantitative Profiling: Harnessing advanced quantification methodologies, we navigate the quantitative landscape of quinones, elucidating their levels and concentrations with an unwavering commitment to accuracy.
Metabolic Pathway Mapping: Our scientific explorations extend beyond individual compounds, encompassing the broader canvas of metabolic pathways. Creative Proteomics is dedicated to unraveling the interconnectedness of quinones with other biomolecules, painting a holistic portrait of cellular orchestration.
| Types | Quinone Compounds |
|---|---|
| Naphthoquinones | Plumbagin, Juglone, Lapachol, Menadione, Lawsone, Alizarin |
| Benzoquinones | Hydroquinone, Coenzyme Q1, Coenzyme Q2, Coenzyme Q3, Coenzyme Q4, Coenzyme Q5 |
| Ubiquinones | Ubiquinone-1 (UQ-1), Ubiquinone-2 (UQ-2), Ubiquinone-3 (UQ-3), Ubiquinone-4 (UQ-4), Ubiquinone-5 (UQ-5), Ubiquinone-6 (UQ-6) |
| Plastoquinones | Plastoquinone-1, Plastoquinone-2, Plastoquinone-3, Plastoquinone-4, Plastoquinone-5, Plastoquinone-6 |
| Other Quinones | Emodin, Menadione Sodium Bisulfite, Embelin, Toluquinol |
The UPLC-MS/MS method we use has the advantages of fast analysis speed and extreme sensitivity, and does not require the use of ion pair reagents. This method can realize effective sample separation, and can realize the detection of trace samples, and the method recovery rate is over 80%.
Figure 2. Quinones analysis service workflow.
Detection method: UPLC-MS/MS
Flow rate: 1.0 ml/min
Injection volume: 1 μl.
Mobile phase: Acetonitrile and 0.2% formic acid as mobile phase
Flow rate: 0.30 ml/min
Measurement mode: multi-reaction monitoring
Monitoring mode: positive ion and negative ion electrospray ionization (ESI)
Analysis content:
| Sample Types | Minimum Sample Size | |
|---|---|---|
| Plant Samples | Roots, stems and leaves, floral parts, fruits/seeds, rhizomes, buds/tender leaves, tissue sections, pollen, bark, trunk/wood, resin/gum, resin acids, seedlings/young plants, rhizosphere soil, root exudates. | 50 mg - 1 g |
| Animal Samples | Urine | 1-2 mL |
| Serum/Plasma | 100-500 µL |
Creative Proteomics presents an array of quinones analysis services that transcend the conventional boundaries of inquiry. Our mission is to unravel the mysteries surrounding quinones and their metabolites, shedding light on their roles within the intricate web of cellular dynamics. Our suite of services encompasses a comprehensive spectrum of quinones analysis, including:
Quinone Identification: Armed with cutting-edge mass spectrometry technologies, Creative Proteomics embarks on precise identification journeys, unraveling the enigmatic identities of quinones and their elusive metabolites lurking within complex biological samples.
Quantitative Profiling: Harnessing advanced quantification methodologies, we navigate the quantitative landscape of quinones, elucidating their levels and concentrations with an unwavering commitment to accuracy.
Metabolic Pathway Mapping: Our scientific explorations extend beyond individual compounds, encompassing the broader canvas of metabolic pathways. Creative Proteomics is dedicated to unraveling the interconnectedness of quinones with other biomolecules, painting a holistic portrait of cellular orchestration.
| Types | Quinone Compounds |
|---|---|
| Naphthoquinones | Plumbagin, Juglone, Lapachol, Menadione, Lawsone, Alizarin |
| Benzoquinones | Hydroquinone, Coenzyme Q1, Coenzyme Q2, Coenzyme Q3, Coenzyme Q4, Coenzyme Q5 |
| Ubiquinones | Ubiquinone-1 (UQ-1), Ubiquinone-2 (UQ-2), Ubiquinone-3 (UQ-3), Ubiquinone-4 (UQ-4), Ubiquinone-5 (UQ-5), Ubiquinone-6 (UQ-6) |
| Plastoquinones | Plastoquinone-1, Plastoquinone-2, Plastoquinone-3, Plastoquinone-4, Plastoquinone-5, Plastoquinone-6 |
| Other Quinones | Emodin, Menadione Sodium Bisulfite, Embelin, Toluquinol |
UPLC-MS/MS method can quickly and highly selectively obtain quinone compound identification and quantitative determination analysis report, helping customers to increase the understanding of the mechanism of action of the active molecules of quinone compound metabolites, and speed up the study of its medicinal value pace. Creative Proteomics has experienced analysis engineers who can provide you with diversified comprehensive solutions and look forward to your cooperation.
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