Metabolomics mainly studies small molecular metabolites with a molecular weight of less than 1500 as substrates and products of various metabolic pathways. By detecting the spectra of a series of samples, combined with chemical pattern recognition methods, qualitative or quantitative analysis of all or some metabolites in the biological system. Metabolomics analysis can determine the pathophysiological state of the birth, gene function, drug toxicity and efficacy, etc., and it is possible to find out related biomarkers. Creative Proteomics' metabolomics services can be applied to many industries, including medicine, pharmacology, pathology, toxicology, food science, nutrition and other fields.
Creative Proteomics' Metabolomics Solutions
Untargeted Metabolomics (Metabolite Profiling) Analysis
Untargeted metabolomics involves the global analysis of metabolites in biological samples. It aims to identify and quantify a wide range of small molecules present in the sample, offering a comprehensive view of the metabolic landscape. Researchers in metabolite profiling are primarily interested in uncovering novel metabolites, identifying metabolic pathways, and understanding how metabolic profiles change under various conditions. This approach is exploratory and hypothesis-generating. Through advanced analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS), we can identify and quantify hundreds to thousands of metabolites simultaneously.
Targeted Metabolomics Analysis
Targeted metabolomics analysis is focused on the precise quantification of specific metabolites of interest. Researchers select and analyze a limited set of compounds with known importance. The focus in targeted analysis is on the accurate measurement of predefined metabolites. This approach is hypothesis-driven and often used for validation or quantitative studies.
Indoles and Indole-sulfur Compounds
Metabolic Pathway Analysis
Metabolic pathway analysis is a crucial step in metabolomics research, as it helps unravel the interconnectedness of metabolites and their involvement in biological processes. Creative Proteomics employs sophisticated bioinformatics tools and databases to map identified metabolites onto metabolic pathways and generate insightful visual representations. This analysis aids in the identification of key metabolic pathways and potential regulatory mechanisms.
Metabolomics Data Analysis and Interpretation
Creative Proteomics understands that the successful interpretation of metabolomics data is crucial for extracting meaningful insights. Our team of expert bioinformaticians and biostatisticians utilizes cutting-edge data analysis algorithms and statistical methods to process raw data, identify significant metabolites, and perform multivariate analyses. This comprehensive approach ensures the accurate interpretation of complex metabolomics datasets.
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Technical Platform for Metabolomics Services
Creative Proteomics utilizes state-of-the-art mass spectrometry techniques for metabolomics analysis, providing high sensitivity, resolution, and coverage of metabolite classes.
Thermo Q ExactiveTM series
AB Sciex 6500+
Thermo Orbitrap Fusion Lumos
Waters Xevo TQ-s
Thermo TRACE 1310-ISQ LT
Thermo TSQ 9000
Agilent 6495 Triple Quadrupole LC/MS Coupled with the Agilent 1290 Infinity II LC System
Acceptable Sample Types
A variety of samples can be analyzed, such as plasma or serum, urine, saliva, cells, animal and plant tissues, fungi, bile acids, microorganisms, cerebrospinal fluid, lymphatic fluid, soil, feces and intestinal flora and other biological samples.
Hot Analytical Metabolite Categories
Applications of Metabolomics Service
Creative Proteomics's metabolomics service offers advanced solutions for exploring and analyzing metabolites, providing valuable insights into diverse areas of research.
Comprehensive profiling and focused study of metabolites in biofluids such blood, urine, and cerebrospinal fluid are made possible by metabolomics. Researchers can find potential biomarkers linked to particular diseases or physiological situations by examining the metabolite patterns.
Metabolomics, for instance, can assist in finding distinctive chemical signatures that distinguish between healthy people and cancer patients in cancer research. These biomarkers can help with early detection, prognosis evaluation, and therapy response tracking.
Metabolomics offers insights into drug metabolism, efficacy, and toxicity. Creative Proteomics's metabolomics service enables researchers to study the metabolic effects of drugs and identify potential drug targets. By analyzing the metabolomic profiles of cells, tissues, or biofluids after drug exposure, researchers can gain a deeper understanding of drug mechanisms of action and evaluate drug safety and efficacy.
Metabolomics can assist in identifying drug metabolites, elucidating metabolic pathways involved in drug metabolism, and predicting drug-drug interactions.
By making it easier to analyze the metabolite profiles of food samples, metabolomics enables researchers to determine the nutritional value, assess the quality of the food, and investigate how different food preparation methods affect metabolite profiles.
Understanding nutrition consumption and metabolism, finding bioactive substances in food, and assessing the impacts of additions or pollutants can all be done with the aid of metabolomics. Understanding the link between diet and health, creating individualized nutrition plans, and assuring the safety and quality of food products are all made easier with the use of this knowledge.
Metabolomics enables the analysis of metabolomic profiles in organisms exposed to environmental stressors or pollutants. By studying the metabolic responses of organisms to environmental changes, researchers can assess the impact on their metabolism and identify potential biomarkers of exposure or effect.
Metabolomics can help in understanding the biochemical pathways involved in the detoxification and metabolism of environmental contaminants. It aids in predicting ecological risks, assessing the effects of pollutants on human health, and contributing to environmental protection efforts.
Plant metabolite profiles may be analyzed more easily due to metabolomics, which reveals details about how plants use their nutrients and respond to biotic and abiotic challenges.
Understanding the biochemical pathways involved in crop development, finding metabolites linked to desired features, and optimizing agricultural techniques for better yield and quality are all possible with the help of metabolomics. This knowledge aids in the development of sustainable agricultural methods, the improvement of crop resistance to diseases, and the breeding of improved crop types.
Systems biology approaches are supported by metabolomics by providing the essential analytical tools and knowledge. Researchers can obtain a comprehensive understanding of biological processes and their regulation by integrating metabolomics data with other "omics" technologies including genomes, transcriptomics, and proteomics. Discovering new metabolic pathways, locating important regulatory nodes, and figuring out how biological phenomena are caused are all made easier by metabolomics. This holistic strategy can be used to model diseases, comprehend cellular metabolism, and find possible treatment targets.
For Research Use Only. Not for use in diagnostic procedures.