Germacrone Analysis Service

What is Germacrone? Why Analyze?

Germacrone, chemically known as (E)-1,6-bis(4-hydroxy-3-methoxyphenyl)-1,3,5-hexatriene, belongs to the sesquiterpene family. Its unique chemical structure comprises a linear carbon chain with alternating double and single bonds, flanked by two hydroxyphenyl groups. This structural arrangement confers germacrone with its remarkable biological properties.

Germacrone has exhibited a wide range of pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and antimicrobial effects. Studies have shown that it can inhibit the growth of various cancer cells, reduce inflammation, scavenge free radicals, and suppress microbial growth. Due to these properties, germacrone has attracted considerable attention from the scientific community as a potential source of new drugs and therapeutic interventions.

Analyzing germacrone is crucial for gaining a comprehensive understanding of its chemical composition, biological properties, and potential applications. It allows researchers to unravel the mechanisms of its action, identify its metabolites, assess its bioavailability, and optimize its extraction and purification methods. Moreover, germacrone analysis helps in exploring its potential as a lead compound for drug discovery and development.

The molecular structure of germacrone

What We Can Provide?

• Germacrone identification and quantification
• Structural characterization
• Germacrone metabolomics profiling

Methods for Germacrone Analysis in Creative Proteomics

Creative Proteomics employs several highly effective techniques to ensure accurate identification, quantification, and characterization of this bioactive compound. The following are the primary methods utilized by Creative Proteomics for germacrone analysis:

1. Liquid Chromatography-Mass Spectrometry (LC-MS)

LC-MS combines the separation power of liquid chromatography with the sensitive detection and identification capabilities of mass spectrometry. Creative Proteomics utilizes LC-MS to separate germacrone from complex mixtures, allowing for precise quantification and structural characterization.

2. High-Performance Liquid Chromatography (HPLC)

HPLC enables the separation, identification, and quantification of germacrone and other components in a sample. By utilizing appropriate columns and optimized mobile phase conditions, Creative Proteomics achieves reliable and accurate results in germacrone analysis.

3. High-Resolution Mass Spectrometry (HR-MS)

HR-MS is employed by Creative Proteomics to obtain precise molecular weight information for germacrone and its metabolites. HR-MS provides superior mass accuracy and resolution, facilitating accurate determination of elemental compositions and structural elucidation.

Workflow of Germacrone Analysis

Sample Requirements of Germacrone Assay

Sample Type: Germacrone analysis can be performed on various sample types, including plant extracts, essential oils, biological fluids, and tissues.

Sample Size: Sufficient sample size is crucial for the accurate detection and quantification of germacrone and its metabolites. For all sample types, a minimum sample size of 10 mg or 10 μL is suggested.

Applications of Germacrone Metabolomics Analysis

Drug Discovery: Germacrone analysis aids in the identification and characterization of novel bioactive compounds that may serve as potential drug leads. By studying the metabolic profiles of germacrone and its derivatives, Creative Proteomics contributes to the discovery of new drug candidates with therapeutic potential.

Traditional Medicine: Germacrone has a long history of use in traditional medicine, particularly in East Asian cultures. Creative Proteomics' analysis provides scientific evidence for the traditional uses of germacrone and supports its integration into modern medicine.

Agricultural Applications: Germacrone analysis assists in understanding the role of germacrone in plant defense mechanisms and its interactions with other organisms. This knowledge can contribute to the development of environmentally friendly agricultural practices and the enhancement of crop yield.

Nutraceuticals and Functional Foods: Germacrone is recognized for its antioxidant and anti-inflammatory properties. Creative Proteomics' analysis contributes to the development and optimization of germacrone-enriched nutraceuticals and functional foods, offering potential health benefits to consumers.