Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Riboflavin Analysis Service

Riboflavin Analysis Service

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Creative Proteomics is a pioneer in metabolic analysis service and provides reliable, professional and cost-effective riboflavin metabolism analysis service in animal. We leverage our rich experience, professional expertise, and advanced technologies to speed up your scientific purposes of riboflavin metabolism analysis in animal.

Overview

Riboflavin (known as vitamin B2), a water-soluble vitamin, is an essential nutrient in vertebrates, hence adequate dietary intake is necessary. Endogenous synthesis of riboflavin by microflora in the large intestine might contribute to a lesser extent. Riboflavin has a role in various metabolic pathways, serving mainly as an integral component of its crucial biologically active forms (flavocoenzymes flavin adenine dinucleotide and flavin mononucleotide). These flavocoenzymes ensure the functionality of tremendous flavoproteins including oxidases, dehydrogenases, monooxygenases and reductases, which play crucial roles in a variety of cellular function including mitochondrial electron transport chain, β-oxidation of fatty acids, redox homeostasis, citric acid cycle, apoptosis and more. It would not be surprisingly that impairment of flavin homeostasis in humans has been connected to various diseases including cardiovascular diseases and neuromuscular disorders. Scientists at Creative Proteomics take advantage of highly quantitative methods with high-performance liquid chromatography (HPLC) for the determination of riboflavin metabolism related metabolites levels in various samples. Furthermore, we provide reliable, rapid and cost-effective riboflavin metabolism related service to speed up your research aims ranging from diseases diagnosis to gaining new insights in disease mechanism or treatment.

The Main Applications of Riboflavin Analysis Service

  • Identifying novel biomarkers of diseases
  • Improving diagnose diseases
  • Accelerating development of novel drugs
  • Gaining new mechanism of diseases

Advantages of Our Riboflavin Analysis Service

  • Constantly optimized protocol and analytical software
  • Professional experiment design
  • Quick turnaround time
  • High accuracy, specificity, and sensitivity

Service Workflow

Creative Proteomics provides riboflavin metabolism analysis service in a reliable and effective manner, based on our cutting-edge HPLC platforms. The experimental procedures contain four main procedures: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

The overall workflow of riboflavin metabolism Figure 1. The overall workflow of riboflavin metabolism

List of Partial Detectable Riboflavin Metabolism Related Metabolites at Creative Proteomics

RibitolFlavin adenine dinucleotide
LumichromeFlavin mononucleotide
RiboflavinDimethylbenzimidazole

Sample Requirements

We can analyze a wide range of biological materials including but not limited to cells and solid tissues from animals. If you need transport your samples to us, please follow the following requirements for different types of sample:

  • Blood/plasma: 500ul/sample
  • Urine: 1ml/sample
  • Tissue: 200mg/sample
  • Cells: 1x107/sample
  • Feces: 500mg/sample
    Shipment condition: dry ice

Report Delivery

  • Experimental protocols
  • Instrumental factors of HPLC
  • The raw data files of HPLC and the summary of HPLC data quality
  • Bioinformatics analysis report

Based on advanced HPLC platforms for the determination of riboflavin metabolism related metabolites, professional bioinformatic analysis software and experienced technicians and scientists, Creative Proteomics provides customer-tailored riboflavin metabolism analysis service with rapid experimental procedures and easy to read report, to accelerate your scientific research.

References

  1. Barile Maria, Giancaspero Teresa Anna, Leone Piero. et al. Riboflavin transport and metabolism in humans. J Inherit Metab Dis. 2016.39:545-557.
  2. Mosegaard Signe, Dipace Graziana, Bross Peter. et al. Riboflavin Deficiency-Implications for General Human Health and Inborn Errors of Metabolism. Int J Mol Sci. 2020.21:3847.
For Research Use Only. Not for use in diagnostic procedures.

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