Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Alpha-Linolenic Acid Metabolism Service

Alpha-Linolenic Acid Metabolism Service

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Alpha-linolenic acid (ALA) is one of the essential unsaturated fatty acids. It is classified as an n-3 series polyunsaturated fatty acid based on its first double bond on the third carbon atom at the methyl end. Alpha-linolenic acid is currently a promising functional ingredient for food, cosmetic and pharmaceutical applications. Creative Proteomics can provide qualitative and quantitative analysis of alpha-linolenic acid to help your project progress.

Overview

Alpha-linolenic acid is a type of omega-3 fatty acid found in many common vegetable oils. Alpha-linolenic acid is one of two essential fatty acids, which animals have to ingest from diet, as the body requires them for tissue function but cannot synthesize them by themselves. Structurally, alpha-linolenic acid comprises an 18-carbon chain and three cis double bonds at positions 9, 12 and 15 from the methyl group. Functionally, alpha-linolenic acid is the substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids like eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3). Therefore, alpha-linolenic acid plays an important role in nutrition and health and its abnormal metabolism cause various human pathologies like cardiovascular disease and cancer.

Alpha-linolenic acid can be used as a drug and food additive to prevent and treat cardiovascular disease, cancer, Alzheimer's disease, vision loss, and other conditions. Foods enriched or supplemented with alpha-linolenic acid are already available in the market, such as milk powder, vegetable oil, snack foods, nutritional powders, and nutraceuticals such as flaxseed oil softgels.

Creative Proteomics offers high performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) tandem technology to determine alpha-linolenic acid levels in a variety of samples.

The Main Applications of Alpha-Linolenic Acid Quantitative Analysis Service

  • Identifying novel biomarkers of diseases
  • Improving diagnose diseases
  • Accelerating development of novel drugs
  • Gaining new mechanism of diseases

Advantages of Our Alpha-Linolenic Acid Quantitative Analysis Service

  • Constantly optimized protocol and analytical software
  • Professional experiment design
  • Quick turnaround time
  • High accuracy, specificity, and sensitivity

Service Workflow

The overall workflow of alpha-linolenic acid metabolism

List of Partial Detectable Alpha-Linolenic Acid Related Metabolites at Creative Proteomics

6,9,12,15,18,21-yetracosahexaenoic acidStearidonic acidEicosatetraeonic acidEicosapentaenoic acidDocosapentaenoic acid
9,12,15,18,21-tetracosapentaenoic acidAlpha-linolenic acidDocosahexaenoic acidTraumatic acidEtherolenic acid

Sample Requirements

  • Blood/plasma: 500ul/sample
  • Urine: 1ml/sample
  • Animal tissue ≥ 50 mg/sample
  • Plant samples: ≥ 200 mg
  • Cells: 1x107/sample
  • Others: Such as food products, drugs, etc.

We can also accept other types of samples. Please contact our technical staff for specific testing requirements.

Report Delivery

  • Experimental procedure
  • Instrument parameters
  • MS raw data files and MS data quality checks
  • Decanoic acid quantification data
  • Custom analysis report

Creative Proteomics offers several approaches to provide alpha-linolenic acid content testing service and deliver precise and detailed data and analysis report. If you want to detect other substances, you can tell us through the inquiry form, and our technicians will communicate with you.

References

  1. Koralek DO, Peters U, Andriole G, et al. A prospective study of dietary α-linolenic acid and the risk of prostate cancer (United States). Cancer Causes & Control. 2006.17: 783–791.
  2. Pan A, Chen M, Chowdhury R, et al. α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. Am. J. Clin. Nutr. 2012. 96: 1262–1273.
For Research Use Only. Not for use in diagnostic procedures.

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