Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Glyoxylate and Dicarboxylate Metabolism Service

Glyoxylate and Dicarboxylate Metabolism Service

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Creative Proteomics, as a leading biotechnology company, offers reliable, fast and cost-effective glyoxylate and dicarboxylate metabolism analysis service in animal. We use our ample experience, professional expertise, and advanced technologies to speed up your scientific purposes of glyoxylate and dicarboxylate metabolism analysis in animal.

Overview

Glyoxylate and dicarboxylate metabolism includes a lot of reactions involving glyoxylate or dicarboxylates. Glyoxylate is the conjugate base of glyoxylic acid, and within a buffered environment of known pH such as the cell cytoplasm. These terms can be used almost interchangeably, as the gain or loss of a hydrogen ion is all that distinguishes them. Similarly, dicarboxylates are the conjugate bases of dicarboxylic acids, a general class of organic compounds containing two carboxylic acid groups like oxalic acid or succinic acid. Glyoxylate and dicarboxylate metabolism is closely related to the Krebs Cycle. When acetyl-coenzyme-A enters the system, it will interact with enzymes within the environment. As one of important carbohydrate metabolisms, glyoxylate and dicarboxylate metabolism play important roles in various diseases like primary hyperoxaluria and Infantile cerebellar-retinal degeneration. As a pioneer in carbohydrate metabolism, Creative Proteomics provides reliable, rapid and cost-effective glyoxylate and dicarboxylate metabolism analysis service to speed up diseases diagnosis and gain new insights in disease mechanism or treatment.

The Main Applications of Glyoxylate and Dicarboxylate Metabolism Service

Identifying novel biomarkers of diseases

Improving diagnose diseases

Accelerating development of drugs

Gaining new mechanism of metabolic diseases

Advantages of Our Glyoxylate and Dicarboxylate Metabolism Service

Ample experience in a variety of animal sample preparation

Advanced core facilities

Professional experiment design and data analysis

Competitive price

Short turnaround time

High accuracy, specificity, and sensitivity

Service Workflow

Creative Proteomics provides glyoxylate and dicarboxylate metabolism service in a reliable and effective manner, based on our cutting-edge high-performance liquid chromatography (HPLC) platforms. The experimental procedures contain four major steps: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

Glyoxylate and dicarboxylate MetabolismFigure 1. The overall workflow of glyoxylate and dicarboxylate metabolism service.

List of Detectable Glyoxylate and Dicarboxylate Metabolism at Creative Proteomics
OxaloacetateOxalateMalate
MalonateMalateIsocitrate
CitrateFumarate

Sample Requirements

We can analyze a wide range of biological materials including but not limited to cells and solid tissues from humans and animals, such as mice, rats, rabbits. If you need transport your samples to us, please follow the below requirements for different kinds of sample:

  • Blood/plasma: 500ul/sample
  • Urine: 1ml/sample
  • Tissue: 200mg/sample
  • Cells: 1x107/sample
  • Feces: 500mg/sample
  • Shipment condition: dry ice

Report Delivery

  • Experimental protocols
  • Instrumental factors of HPLC
  • The raw data files of HPLC and the summary of HPLC data quality
  • Bioinformatics analysis report

Based on advanced HPLC platforms for the determination of glyoxylate and dicarboxylate metabolism, professional bioinformatic analysis software and experienced technicians and scientists, Creative Proteomics provides customer-tailored glyoxylate and dicarboxylate metabolism analysis service with rapid experimental procedures and easy to read report, to accelerate your scientific research.

References

  1. Satu Mikkola. Nucleotide Sugars in Chemistry and Biology. Molecules, 2020, 25:5755.
  2. Christopher J. Danpure. Primary hyperoxaluria type 1: AGT mistargeting highlights the fundamental differences between the peroxisomal and mitochondrial protein import pathways. Biochim Biophys Acta. 2006,1763:1776-1784.
  3. Ronen Spiege, Ophry Pines, Asaf Ta-Shma. et all. Infantile cerebellar-retinal degeneration associated with a mutation in mitochondrial aconitase, ACO2. Am J Hum Genet. 2012, 90:518-523.
For Research Use Only. Not for use in diagnostic procedures.

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