Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Glycolysis Metabolism Service

Glycolysis Metabolism Service

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Creative Proteomics, as a leading biotechnology company, provides reliable, rapid and cost-effective glycolysis metabolism analysis service in animal. We leverage our experience, expertise, and technologies to accelerate your scientific research of glycolysis pathway metabolites analysis in animal.

Overview

Glycolysis is a common metabolic pathway in almost all cells. It takes place in the cytoplasm of a cell. By converting six-carbon glucose into two molecule of the three‐carbon compound pyruvate and generating two ATPs, glycolysis generates the adenosine triphosphate (ATP) needed for energy‐requiring processes and the pyruvate needed for the complete oxidation of glucose to carbon dioxide and water (Figure1)1. For cells without mitochondria like red blood cells, the glycolysis is the only energy source of ATP. For cells containing mitochondria, glycolysis as a preparatory pathway for the complete oxidation of glucose to generate larger amounts of ATP. Glycolysis is used by all cells in the body for energy generation. The final product of glycolysis is pyruvate in aerobic settings and lactate in anaerobic conditions. Glycolysis defects therefore lead to various diseases like cancer2. As a high-throughput tool, glycolysis metabolites analysis provides a powerful way to diagnosis and gain new insights in disease mechanism or treatment. With integrated array of separation, characterization, identification and quantification experience, Creative Proteomics provides reliable, rapid and cost-effective glycolysis metabolism for your various scientific purposes.

The Main Applications of Glycolysis Metabolism Service

Biomarker discovery

Disease diagnostics

Drug discovery

Food safety

Metabolic disease research

Glycolysis Metabolism ServiceFigure 1. Glycolysis: the glucose oxidative pathway at cellular levels.

Advantages of Our Glycolysis Metabolism Service

Rich experience in different types of animal sample preparation

State of art facilities

Professional experiment design and data analysis

Competitive price

Short turnaround time

High accuracy, specificity, and sensitivity

Service Workflow

The glycolysis metabolism service provided by Creative Proteomics is based on our cutting-edge chromatographic separation and mass spectrometry platforms. The experimental workflow involves 4 steps: sample collection, metabolites extraction, MS data analysis and bioinformatics analysis (Figure 2). Our service will be tailored to specific samples and needs for optimal results.

overall workflow of glycolysis metabolism serviceFigure 2. The overall workflow of glycolysis metabolism service.

List of Detectable Glycolysis Metabolites at Creative Proteomics

Sample Requirements

We can analyze any biological materials including but not limited to cells and solid tissues from humans and animals, such as mice, rats, rabbits.  If you need transport your samples to us, please follow the below requirements for different types of sample:

  • Blood/plasma: 500ul/sample
  • Urine: 1ml/sample
  • Tissue: 200mg/sample
  • Cells: 1x107/sample
  • Feces: 500mg/sample
  • Shipment condition: dry ice

Report Delivery

  • Experimental procedures
  • Instrument parameters of liquid chromatography and mass spectrometry
  • MS raw data files and the summary of mass spectrometry data quality
  • The identification/quantification of lipidic molecules data
  • Bioinformatics analysis report (PCA, KEGG, etc.)

Equipped with advanced mass spectrometry for the determination of carbohydrate metabolites, powerful bioinformatic analysis software and a panel of experienced technicians and scientists, we provide customer-tailored targeted glycolysis pathway metabolites analysis services with rapid experimental procedures and easy to read report, to advance your scientific research.

References

  1. Arren Bar-Even, Avi Flamholz, Elad Noor and Ron Milo.Rethinking glycolysis: on the biochemical logic of metabolic pathways. Nat Chem Biol. 2012,8:509-517.
  2. Robert A Gatenby, Robert J Gillies. Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell Biol. 2007,39:1358-1366.
For Research Use Only. Not for use in diagnostic procedures.

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