Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Inositol Phosphates Metabolism Service

Inositol Phosphates Metabolism Service

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Creative Proteomics is a leading biotechnology company which can offer reliable, professional and cost-effective inositol phosphate metabolism analysis service in animal. We leverage our rich experience, professional expertise, and advanced technologies to speed up your scientific purposes of inositol phosphate metabolism analysis in animal.

Overview

Inositol phosphates (IPs) are a group of mono to hexa-phosphorylated inositols. They play critical roles in diverse cellular functions including cell growth, apoptosis, cell migration, endocytosis and cell differentiation. Mono-, di-, and triphosphorylation of the inositol ring creates a wide range of stereochemically distinct signalling entities. For instance, inositol 1,4,5-trisphosphate (I(1,4,5)P3), is formed when the phosphoinositide phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is hydrolysed by a phospholipase C isozyme. An array of inositol trisphosphate (IP3) and tetrakisphosphate (IP4) molecules are synthesised by the action of various kinases and phosphatases in the cytosol. These species then transport between the cytosol and the nucleus where they are acted on by inositol polyphosphate multikinase (IPMK), inositol-pentakisphosphate 2-kinase (IPPK), inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2), to produce IP5, IP6, IP7, and IP8 molecules. As a carbohydrate metabolism, inositol phosphate metabolism plays important roles in mammalians. Thus, its dysfunction is closely associated with various diseases like Joubert syndrome and Centronuclear myopathy. In Creative Proteomics, we provide reliable, rapid and cost-effective inositol phosphate analysis service to speed up your research aims ranging from diseases diagnosis to gaining new insights in disease mechanism or treatment.

The Main Applications of Inositol Phosphates Metabolism Service

Identifying novel biomarkers of diseases

Improving diagnose diseases

Accelerating development of novel drugs

Gaining new mechanism of diseases

Advantages of Our Inositol Phosphates Metabolism Service

Ample experience in a variety of animal sample preparation

State of the art facilities

Professional standard operation procedure

Low cost

Short experimental time

High accuracy, specificity, and sensitivity

Service Workflow

Creative Proteomics offers inositol phosphate metabolism service in a reliable and effective manner, based on our cutting-edge high-performance liquid chromatography (HPLC) platforms. The experimental procedures contain four main procedures: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

Inositol phosphate metabolism-1.pngFigure 1. The overall workflow of inositol phosphate metabolism service.

The Potential Detectable Inositol Phosphates Related Metabolites at Creative Proteomics
PhytateMyo-inositolBornesitol
Phosphatidylinositol-3,4,5-trisphosphate1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol 3-phosphate
D-myo-Inositol 1,3-bisphosphate1D-myo-Inositol 3-phosphate1D-myo-Inositol 1,3,4,5,6-pentakisphosphate

Sample Requirements

We can analyze a wide range of biological materials including but not limited to cells and solid tissues from humans and animals, such as mice, rats, rabbits. If you need transport your samples to us, please follow the below requirements for different kinds of sample:

  • Blood/plasma: 500ul/sample
  • Urine: 1ml/sample
  • Tissue: 200mg/sample
  • Cells: 1x107/sample
  • Feces: 500mg/sample
  • Shipment condition: dry ice

Report Delivery

  • Experimental procedures
  • Instrumental factors of HPLC
  • The raw data files of HPLC and the summary of HPLC data quality
  • Bioinformatics analysis report

Based on advanced HPLC platforms for the determination of propanoate metabolism, professional bioinformatic analysis software and experienced technicians and scientists, Creative Proteomics provides customer-tailored propanoate metabolism analysis service with rapid experimental procedures and easy to read report, to accelerate your scientific research.

References

  1. Monserrate Jessica P, York John D. Inositol phosphate synthesis and the nuclear processes they affect. Curr Opin Cell Biol. 2010,22:365-373.
  2. Bunney Tom D, Katan Matilda. Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer. 2010.10:342-352.
  3. Bielas Stephanie L, Silhavy Jennifer L, Brancati Francesco, et al. Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Nat Genet. 2009,41:1032-1036.
  4. Agrawal Pankaj B, Pierson Christopher R, Joshi Mugdha, et al. SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy. Am J Hum Genet. 2014, 95:218-226.
For Research Use Only. Not for use in diagnostic procedures.

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