Amino Sugar and Nucleotide Sugar Metabolism Service

Overview

Amino sugars are chemical compounds that have a sugar backbone, in which one of the hydroxyl groups is replaced by an amine group. Glucosamine, galactosamine and neuraminic acid are three major types of amino sugars. In contrast, nucleotide sugars are the activated forms of monosaccharides. Nucleotide sugars act as glycosyl donors in glycosylation reactions via glycosyltransferases. Both amino sugars and nucleotide sugars play important roles in regulating protein function. It would not be surprising that aberrant amino sugar and nucleotide sugar metabolism links to various diseases like galactosemia and distal myopathy. As a high-throughput tool, amino sugar and nucleotide sugar metabolism analysis provides a powerful way to diagnosis and gain new insights in disease mechanism or treatment. With integrated array of separation, characterization, identification and quantification experience, Creative Proteomics provides reliable, rapid and cost-effective amino sugar and nucleotide sugar metabolism analysis service for your various scientific purposes.

The Main Applications of Amino Sugar and Nucleotide Sugar Metabolism Service

Biomarker discovery

Disease diagnostics

Drug discovery

Metabolic disease research

Advantages of Our Amino Sugar and Nucleotide Sugar Metabolism Service

Rich experience in different types of animal sample preparation

State of art facilities

Professional experiment design and data analysis

Competitive price

Short turnaround time

High accuracy, specificity, and sensitivity

Service Workflow

The amino sugar and nucleotide sugar metabolism service provided by Creative Proteomics is based on our cutting-edge high-performance liquid chromatography (HPLC) platforms. The experimental workflow involves 3 steps: sample collection, metabolites extraction, HPLC data analysis and bioinformatics analysis (Figure 1). Our service will be tailored to specific samples and needs for optimal results.

Figure 1. The overall workflow of amino sugar and nucleotide sugar metabolism service.

List of Detectable Amino Sugar and Nucleotide Sugar Metabolism at Creative Proteomics

Glucosamine	Galactosamine	Neuraminic acid
Uridine diphosphate glucose	Guanosine diphosphate mannose	Uridine diphosphate galactose
Uridine diphosphate glucuronic	Guanosine diphosphate fucose	Uridine diphosphate N-acetyl glucosamine
Uridine diphosphate N-acetyl galactosamine	Uridine diphosphate xylos	Cytidine monophosphate N-acetyl neuraminic acid

Sample Requirements

We can analyze any biological materials including but not limited to cells and solid tissues from humans and animals, such as mice, rats, rabbits. If you need transport your samples to us, please follow the below requirements for different types of sample:

• Blood/plasma: 500ul/sample
• Urine: 1ml/sample
• Tissue: 200mg/sample
• Cells: 1x10⁷/sample
• Feces: 500mg/sample
• Shipment condition: dry ice

Report Delivery

• Experimental procedures
• Instrument parameters of liquid chromatography
• HPLC raw data files and the summary of HPLC data quality
• The identification/quantification of lipidic molecules data
• Bioinformatics analysis report (PCA, KEGG, etc.)

Equipped with advanced mass spectrometry for the determination of amino sugar and nucleotide sugar metabolism, powerful bioinformatic analysis software and a panel of experienced technicians and scientists, we provide customer-tailored amino sugar and nucleotide sugar metabolism analysis service with rapid experimental procedures and easy to read report, to advance your scientific research.

References

1. Satu Mikkola. Nucleotide Sugars in Chemistry and Biology. Molecules, 2020, 25:5755.
2. Kleta Robert, et al. Clinical, biochemical, and molecular diagnosis of a free sialic acid storage disease patient of moderate severity. Mol Genet Metab. 2004,82:137-143.
3. Udd Bjarne. Genetics and pathogenesis of distal muscular dystrophies. Adv Exp Med Biol,2009,652:23-38.