Quinolinic Acid Analysis Service

Quinolinic acid (QUIN) is also known as 2,3-pyridinedicarboxylic acid. Quinolinic acid is one of the metabolites of tryptophan (Trp) and a selective agonist of N-methyl-D-aspartate (NMDA) receptor, which is associated with the occurrence and development of certain neuropsychiatric diseases, renal diseases, immune diseases, etc. Therefore, the determination of quinolinic acid in biological specimens is of great importance. In order to better understand the presence and dynamics of quinolinic acid in experimental animals and humans, Creative Proteomics can provide you with quinolinic acid content determination services to accelerate your project.

Targeted metabolomics is a metabolome method for detecting a certain substance or a certain type of metabolites. It has the advantages of strong specificity, high detection sensitivity and accurate quantification. We use the AB SCIEX 5500 QQQ UPLC-MS LC/MS instrument to detect the content of low abundance compounds. The absolute abundance information of the target metabolite can be obtained by comparing with the standard product.

Molecular structure of quinolinic acid

Technical Route of Targeted Metabolomics of Quinolinic Acid

Sample Requirements

• Animal tissues ≥ 200 mg /sample
• Serum/Plasma ≥ 200 mL/sample
• Urine ≥ 1 mL/sample
• Feces ≥ 500 mg/sample
• Cells ≥ 1x10⁷/sample

We can also accept other types of samples, please contact our technical staff for details.

Feedback to Customers

• Experimental procedures
• The parameters of liquid chromatograph and mass spectrometer
• HPLC and MS raw data files
• Metabolite quantitative data

Creative Proteomics offers several approaches to provide quinolinic acid quantitative analysis service. We will deliver precise and detailed data and analysis report. If you want to detect other substances, you can tell us through the inquiry form, and our technicians will communicate with you.

References

1. Riera-Borrull M, Rodríguez-Gallego E, Hernández-Aguilera A, et al. Exploring the process of energy generation in pathophysiology by targeted metabolomics: performance of a simple and quantitative method. Journal of the American Society for Mass Spectrometry, 2015, 27(1): 168-177.
2. Kim M J, Lee M Y, Shon J C, et al. Untargeted and targeted metabolomics analyses of blackberries – Understanding postharvest red drupelet disorder. Food Chemistry, 2019, 300:125169.
3. Wang X, Zhao X, Zhao J, et al. Serum metabolite signatures of epithelial ovarian cancer based on targeted metabolomics. Clinica Chimica Acta, 2021, 518: 59-69.