Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Pantothenic Acid Analysis Service

Pantothenic Acid Analysis Service

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Creative Proteomics' targeted metabolomics services target specific metabolites and pathways of interest, which can accurately monitor dynamic metabolic processes, reveal related metabolic mechanisms and verify potential metabolic biomarkers, to guide your research with reliable and accurate measurement results.

About Pantothenic Acid

Pantothenic acid, also known as vitamin B5, is a water-soluble vitamin, named "pantothenic acid" because it is widely present in plants and animals. Since all foods contain pantothenic acid, there is almost no deficiency problem.

All animals need pantothenic acid to synthesize coenzyme A (CoA), which is essential for fatty acid metabolism, and can also synthesize or metabolize protein, carbohydrates and fats.

Pantothenic acid can be used as a coloring aid in the food industry, and it is also used as a food fortifier in bread, cakes and dairy products. In cosmetics, it protects and improves rough skin.

Pantothenic acid is optically active, and only D type has biological activity. Its chemical formula is C9H17NO5, and CAS number are 599-54-2 and 79-83-4(R).

MS-based technical means can realize the qualitative and quantitative analysis of pantothenic acid.

Molecular structure of pantothenic acidMolecular structure of pantothenic acid

Technical Route of Targeted Metabolomics of Pantothenic Acid

Technical Route of Targeted Metabolomics of Pantothenic Acid

Sample Requirements

Sample type
Plants, yeasts, microorganisms, etc.
     Serum, plasma, urine, bile, bile acid, etc.
     Cells, liver, brain tissue and other animal tissues and feces, etc.
     There is no restriction on plant varieties. For varieties with special requirements or rare varieties, please contact our staff for more information.
Sample demand
Plant root / stem / leaf / fruit / seed > 200 mg fresh weight, freeze-dried sample > 0.5 g
Cells / microorganisms / cell supernatant / culture medium supernatant: the number of cells or bacteria > 107, supernatant > 2 ml
Serum / plasma / urine / ruminal fluid / cerebrospinal fluid / amniotic fluid and other homogeneous liquid samples > 200 µl.
(Hemolysis should be avoided. Cerebrospinal fluid can be as low as 100 µl.)
Animal tissue / feces related samples > 200mg / sample
For other sample types, please consult technical support or sales.
Sample mixed and repeat
In order to ensure the accuracy of the samples and reduce systematic errors during sampling, it is necessary to select more than 3 materials with the same condition for each sample.
    ※ The same condition refers to the same period, basically the same phenotype, and the same part.
It is recommended that prepare more than 6 biological replicates.
Storage and transportation
Quick-frozen preservation with liquid nitrogen can minimize the leakage time of plant samples at room temperature, and store it at -80℃.
Dry ice transportation (about 3~4 kg dry ice is consumed every day, please use sufficient dry ice for transportation).

References

  1. D Tsoukalas, Alegakis A, Fragkiadaki P, et al. Application of metabolomics: Focus on the quantification of organic acids in healthy adults. International Journal of Molecular Medicine, 2017.
  2. Pawlak M, Klupczynska A, Kokot Z J, et al. Extending Metabolomic Studies of Apis mellifera Venom: LC-MS-Based Targeted Analysis of Organic Acids. Toxins, 2019, 12(1):14.
  3. Xin, Wang, Tao, et al. Targeted Metabolomic Profiling Reveals Association Between Altered Amino Acids and Poor Functional Recovery After Stroke. Frontiers in neurology, 2019, 10:1425-1425.
  4. Wang X, Zhao X, Zhao J, et al. Serum metabolite signatures of epithelial ovarian cancer based on targeted metabolomics. Clinica Chimica Acta, 2021, 518: 59-69.
For Research Use Only. Not for use in diagnostic procedures.

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