Metabolomics Creative Proteomics

Creative Proteomics Metabolomics

Berberine Analysis Service

Berberine Analysis Service

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Overview

Berberine is an isoquinoline alkaloid, a natural extract from the root lotus of the genus Xanthophyllum active ingredient. Berberine has various pharmacological effects, including anti-pathogenic microorganism, anti-inflammatory, anti-tumor, cardioprotection, hypoglycemia, regulation of lipid metabolism, and immunosuppression. For many years, berberine has been used in the treatment of intestinal infectious diseases with remarkable efficacy. As research continues to progress, its potential for clinical application continues to be developed, with promising results in cardiovascular system diseases, metabolic syndrome and its complications, tumors, abdominal adhesions, and Chlamydia trachomatis infections.

Creative Proteomics uses high performance liquid chromatography (HPLC) and liquid mass spectrometry (LC-MS) techniques for efficient and accurate detection of changes in berberine content. In addition, we offer a variety of other alkaloid assays to meet your different needs.

Molecular structure of berberineMolecular structure of berberine

Platform

  • HLPC
  • LC-MS/MS

Workflow of targeted metabolomics service of berberine

Targeted metabolomics is a study that identifies and quantitatively analyzes known metabolites in a sample. Its advantages are high specificity and accuracy. Therefore, this method has been widely used to analyze and compare multiple target metabolites in different physiological states.

Workflow of targeted metabolomics service of berberine

Sample requirements

  • Tissue ≥ 200 mg/sample
  • Plasma ≥ 200 μL/sample
  • Blood ≥ 200 μL/sample
  • Drugs ≥ 0.2 g/sample

We can also accept other samples. Please contact us for the exact sample size required for the test.

In order to ensure the accuracy of the samples and reduce systematic errors during sampling, it is necessary to select more than 3 materials with the same condition for each sample. The same condition refers to the same period, basically the same phenotype, and the same part.

Delivery standard

  • Complete lab report (including information on methods, instrument parameters, reagents, and consumables)
  • Raw data
  • Mass spectrum picture (section)
  • Metabolic molecular identification results

Turnaround time: About 1-4 weeks.

Creative Proteomics has leading technology, first-class R&D and production equipment. Our professional team has many years of experience in metabolomics, bioinformatics, and statistics, and can help you plan, conduct and report metabolomics research, so that your upstream and downstream experiments can be seamlessly connected. We can provide a wide range of target metabolomics services, including target metabolic pathways, target metabolite analysis, etc. You can also perform personalized customization services at the same time during the data analysis stage. If you have any questions or specific requirements, please feel free to contact us.

References

  1. Kim H, Bu Y, Lee B J, et al. Myristica fragrans seed extract protects against dextran sulfate sodium-induced colitis in mice. [J]. Journal of Medicinal Food, 2013, 16(10):953.
  2. Yao Y, Wang G B, Man S L, et al. Toxicological advances of traditional medicine in 2019[J]. Traditional Medical Research (TMR), 2020, 005(002):P.83-89.
  3. Luca V D, Salim V, Atsumi S M, et al. Mining the Biodiversity of Plants: A Revolution in the Making[J].Science, 2012.
For Research Use Only. Not for use in diagnostic procedures.

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