Ornithine Analysis Service

What is Ornithine?

Ornithine is a non-proteinogenic amino acid that holds pivotal significance in the intricate landscape of biological processes. It plays a crucial role in the urea cycle, a metabolic pathway responsible for detoxifying ammonia in the body. Ornithine is a key player in the synthesis of proteins and contributes to the production of polyamines, influencing various physiological functions.

Ornithine metabolism is a complex network of biochemical reactions in which ornithine undergoes transformations critical to maintaining metabolic balance. Primarily associated with the urea cycle, ornithine participates in reactions regulating ammonia levels, supporting collagen synthesis, and contributing to the biosynthesis of other amino acids. Understanding these metabolic pathways is fundamental to unraveling the multifaceted functions of ornithine.

Why Choose Ornithine Analysis?

• Metabolic Pathway Understanding: Gain a deeper understanding of metabolic pathways by analyzing ornithine and its associated metabolites.
• Disease Diagnosis and Treatment: Detect abnormalities related to ornithine metabolism early on, aiding in the diagnosis and timely treatment of genetic disorders and other health conditions.
• Drug Development: Utilize insights into ornithine functions to design targeted drugs, fostering advancements in therapeutic interventions.

Ornithine Analysis by Creative Proteomics

Ornithine Quantitative Analysis: Precise measurement of ornithine levels in biological samples using advanced analytical techniques. Quantification based on established standards to ensure accuracy and reproducibility.

Ornithine Purity Assessment: Evaluation of the purity of ornithine samples, crucial for applications in research and development. Identification and quantification of impurities if present.

Ornithine Structural Analysis: Elucidation of the molecular structure of ornithine using state-of-the-art instrumentation. Structural confirmation through techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.

Customized Analysis: Tailored services to meet specific project requirements and research goals. Flexibility to adapt methodologies based on the unique characteristics of the sample.

Quality Control: Stringent quality control measures to ensure the reliability and precision of the results. Compliance with industry standards and regulations.

Data Interpretation and Reporting: Thorough analysis and interpretation of the obtained data. Clear and comprehensive reporting, including detailed methodologies and results.

Confidentiality: Adherence to strict confidentiality protocols to protect the client's proprietary information. Secure handling of samples and data throughout the analysis process.

Ornithine Assay Platforms

Creative Proteomics employs state-of-the-art mass spectrometry-based techniques for ornithine analysis. Our analytical methodologies leverage advanced instrumentation, including high-performance mass spectrometers such as the Thermo Scientific Orbitrap series (e.g., Orbitrap Fusion, Orbitrap Elite) and the Waters Xevo series. These cutting-edge instruments enable precise and sensitive detection of ornithine, ensuring accurate quantification and reliable structural analysis.

The use of high-resolution mass spectrometry allows for the identification and quantification of ornithine with exceptional accuracy. Additionally, tandem mass spectrometry (MS/MS) techniques, such as collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD), enhance the specificity and selectivity of the analysis, enabling a more in-depth understanding of the molecular structure of ornithine.

Our analytical approach involves the integration of chromatographic separation techniques, such as liquid chromatography (LC) or gas chromatography (GC), coupled with mass spectrometry. This combination enhances the separation of complex mixtures, providing a robust platform for the analysis of ornithine in various sample matrices.

Furthermore, our experienced scientists are adept at method development and optimization, ensuring that the chosen analytical techniques are tailored to the specific requirements of ornithine analysis. This includes optimizing parameters such as chromatographic conditions, ionization methods, and mass spectrometer settings to achieve optimal sensitivity and resolution.

Sample Requirements of Ornithine Analysis